https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23780 Wed 11 Apr 2018 15:15:03 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9438 Wed 11 Apr 2018 13:03:07 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23777 Wed 11 Apr 2018 11:49:29 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46700 Tue 29 Nov 2022 09:49:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40857 Tue 19 Jul 2022 13:42:18 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43097 Tue 13 Sep 2022 12:40:26 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40874 Tue 07 Nov 2023 15:52:03 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38092 Tue 03 Aug 2021 18:28:49 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39965 Thu 30 Jun 2022 16:42:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40024 Thu 21 Jul 2022 09:47:00 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8131 .05, t-test). Diffuse cortical atrophy was detected for both ε4+ (p = .0001, permutation test) and ε4− patients (p = .0001, permutation test) relative to controls, and overall gray matter loss was about 15% in each patients group. Differences in gray matter loss between carriers and non-carriers mapped to the temporal cortex and right occipital pole (20% greater loss in carriers) and to the posterior cingulate, left orbitofrontal and dorsal fronto-parietal cortex (5–15% greater loss in non-carriers). APOE effect in AD was not significant (p > .74, ANOVA), but a significant APOE by region (temporal vs fronto-parietal cortex) interaction was detected (p = .002, ANOVA), in both early and late-onset patients (p < .05, ANOVA). We conclude that the ε4 allele modulates disease phenotype in AD, being associated with a pattern of differential temporal and fronto-parietal vulnerability.]]> Sat 24 Mar 2018 08:40:03 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1875 Sat 24 Mar 2018 08:31:16 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2966 Sat 24 Mar 2018 08:30:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1711 Sat 24 Mar 2018 08:27:39 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1712 Sat 24 Mar 2018 08:27:39 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10763 Sat 24 Mar 2018 08:13:54 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10285 Sat 24 Mar 2018 08:09:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10902 Sat 24 Mar 2018 08:09:03 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20050 Sat 24 Mar 2018 08:00:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17996 Sat 24 Mar 2018 07:56:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17935 0.29). Hippocampal surface analysis showed the typical pattern of CA1 and subicular tissue atrophy in both ε4-carriers and non-carriers compared with controls (e4 carriers: p < 0.0002; ε4 non-carriers: p < 0.01, permutation test). The left hippocampal volume was significantly smaller in ε4-carriers than non-carriers (p = 0.044, Mann–Whitney test), the effect of APOE4 mapping to the subicular/CA1 region (p = 0.041, permutation test). Differences were not statistically significant in the right hippocampus (p > 0.20, permutation test). These findings show that hippocampal atrophy is greater in APOE4 carriers in regions typically affected by pathology. APOE4 may affect the structural expression of Alzheimer's disease.]]> Sat 24 Mar 2018 07:56:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26154 Sat 24 Mar 2018 07:35:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22195 Sat 24 Mar 2018 07:16:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24047 Sat 24 Mar 2018 07:09:37 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35143 Fri 31 Jan 2020 15:47:10 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54939 Fri 22 Mar 2024 14:38:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51370 Fri 01 Sep 2023 13:43:45 AEST ]]>